protein-proteininteraction相关论文
为了进一步研究胰蛋白酶的保鲜机制,探讨火龙果中胰蛋白酶和抗氧化酶的协同机制,根据胰蛋白酶调控火龙果的RNA-seq数据筛选活性氧(......
Pulmonary fibrosis (PF) is a chronic,progressive,fatal interstitial lung disease with limited available therapeutic stra......
Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-inte
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a global health threat since December 2019,and the......
Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its trans-Golgi network localiz
Varicella-zoster virus (VZV) is a neurotropic alphaherpesvirus that causes chickenpox and shingles.ORF7 is an important ......
The baculovirus late expression factor 11(LEF-11)has been reported to be involved in viral DNA replication and late/very......
TRIB3 Supports Breast Cancer Stemness by Suppressing FOXO1 Degradation and Enhancing SOX2 Transcript
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目的 High TRIB3 expression was found in lung cancer tissues and positively correlated with EGFR expression level.The eff......
High Glucose-induced TRIB3 Promotes CRC Tumorigenesis and Progression via Upregulating Wnt/betacaten
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A novel small fluorescent probe based naphthalimided derivation for detecting and imaging p53-MDM2 i
Fluorescent techniques play critical role in detection,high-throughput screening,imaging for biomolecules and protein,in......
Introduction: Junctophilins(JPs)are membrane-binding proteins within the junctional membrane complexs,which can bind bot......
In the HIV-1 replication cycle,the ESCRT(endosomal sorting complex required for transport)machinery facilitates viral bu......
Hypoxia-inducible factor-2(HIF-2)is a heterodimeric transcription factor formed through the dimerization of an oxygensen......
Two interacting proteins form an ensemble of non-specific encounter complexes, facilitating the formation of the specifi......
As an important and challenging issue of biomedical information extraction,protein-protein interaction (PPI) extraction ......
With the development of Protein-Protein Interaction (PPI) researches,an abundance of PPI information has been deposited ......
Analysis of differentially expressed microRNAs and genes in cervical cancer using an integrated bioi
To identify microRNAs and mRNA associated with carcinogenesis of cervical cancer and investigate the molecular mechanism......
Super-resolution Imaging and Tracking of Protein-Protein Interactions in Sub-diffraction Cellular Sp
Imaging localization and dynamics of individual interacting protein pairs is essential but often difficult due to the fl......
Elucidation of the interaction mode of an HIV transcription inhibitor by comparative docking studies
HIV-1 transcription is a critical step in the viral life cycle.It is controlled by multiple cellular factors and transcr......
Structure-Activity and Structure-Property Relationship and Exploratory in vivo Evaluation of the Nan
Directly disrupting the Keap1-Nrf2 protein-protein interaction(PPI)has been proven an effective way to activate Nrf2.On ......
Breast cancers are a heterogeneous group of diseases with distinct and complex mechanisms of pathogenesis.1 Triple-negat......
Motivation: Proteins usually fulfill their biological functions through interacting with other proteins.Although some me......
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Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses ce
Signaling through the Rho family of small GTPases has been intensely investigated for its crucial roles in a wide variet......
Background: C-terminal binding protein(CtBP)is encoded by two similar genes in the vertebrates,CtBP1 and CtBP2.Both CtBP......
An Efficient and Versatile Tool for Lead Structure Generation and Optimization in Structure-based Dr
In structure-based drug design,docking-based virtual screening is widely applied to lead discovery.Other types of method......
Molecular Basis of the Interaction for an Essential Subunit PA-PB1 in Influenza Virus RNA Polymerase
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The formation of p38 MAPK and MAPK-activated protein kinase 2 (MK2) signaling complex is physiologically relevant to cel......
Toll-like receptors(TLRs)are highly conserved transmembrane proteins which detect pathogen-associated molecular patterns......
Continuous efforts have been invested in developing constrained peptides for modulating PPIs by enhancing the peptides h......
Peripheral T-cell lymphoma (PTCL) is a very aggressive and heterogeneous hematological malignancy and has no effective t......
With the development of the new detection methods and the function of fluorescent molecule, researchers hope to further ......
Screening of small molecular inhibitors targeting at Toxoplasma gondii autophagy-related protein TgA
Objective: To acquire small molecule inhibitors that could significantly reduce the proliferation of Toxoplasma gond......
Cotton PIP2 proteins selectively interact to regulate their water channel activities and are require
Aquaporins are small channel proteins present in plasma and intracellular membranes of plant cells, facilitating the tra......
Designing functional proteins is the ultimate test for our understandings of protein structure and function relation......
Background: Pathways provide important information about how genes interact with each other in a concerted way.Never......
Background: Pathway databases, especially KEGG, have been widely used as a reference knowledge base for biomedical s......
Background: Previous results indicated that the CDK2/Cyclin E1 protein complex, which plays a key role in regulating......
A set of proteins interacting with papaya ringspot virus (PRSV) Nia-Pro protein identified in a two-
The protein-protein interactions between viral proteins and host factors have crucial roles in plant virus infection and......
SPOP plays a key role for the tumorigenesis in kidney.Previous research found that protein SPOP obviously overexpres......
Biological macromolecular interactions form the basis of many essential processes in cellular activities.Molecular m......
高通量酵母双杂交与免疫亲和纯化技术的快速发展和日臻成熟,使得在蛋白质组水平上大规模地研究蛋白质之间的相互作用成为可能。目......
Identifying changed protein-protein interactions in biological processes by gene coexpression analys
在 2 蛋白质之间的相互作用力量不在不同条件下面不变却可变。为一个给定的生物过程，在相互作用力量经历动态变化的蛋白质蛋白质相......
目前，蛋白质相互作用已成为蛋白质组学研究的热点．新方法的建立及对已有技术的改进标志着蛋白质相互作用研究的不断发展和完善．在技术......
Interaction specific binding hotspots in Endonuclease colicin-immunity protein complex from MD simul
The binding of Endonuclease colicin 9 (E9) by Immunity protein 9 (Im9) was found to involve some hotspots from helix III......
Expression Profiles and Protein Complexes of StarchBiosynthetic Enzymes from White-Core and Waxy Mut
Physicochemical properties of endosperm starches in milled rice determine its cooking and eating quality. Amylose is syn......
Gel-Based Chemical Cross-Linking Analysis of 20S Proteasome Subunit-Subunit Interactions in Breast C
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GTB-PPI:Predict Protein–protein Interactions Based on L1-regularized Logistic Regression and Gradien
Protein–protein interactions (PPIs) are of great importance to understand genetic mech-anisms, delineate disease pathog......
A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Ca
The E3 ligase adaptor SPOP,overexpressed in the nucleus but frequently dislocated into the cytoplasm in all clear cell R......
